The ML350 comes with a 3.5L, 60-degree V6 with high-pressure direct injection, which results in 302 horsepower.
Ride quality of the M-Class is smooth, quiet and absorbent, yet steering response is quite sharp. Among the M-Class' many active and passive safety features offered are Lane Keeping Assist, Blind Spot Assist, a Night View Assist night-vision system with pedestrian detection, Distronic Plus adaptive cruise control, a Pre-Safe Brake system that will help brake if a collision is anticipated and a special lighting package. Attention Assist studies patterns in the driver's fine steering adjustments, can identify fatigue and drowsiness, chiming and flashing a coffee cup icon on the instrument panel.
Mercedes-Benz' COMAND screen-based interface is standard, including a 7-inch display, Bluetooth audio and hands-free calling, cover-art display, a USB port and a 6-disc changer. Meanwhile, the instrument cluster has its own reconfigurable, 4.5-inch display.